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gene2003.pdf
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Researchers present a novel test for detecting excess radical amino-acid replacements in phylogenetic trees, indicative of positive Darwinian selection. The test characterizes each replacement by physicochemical distance and identifies significant deviations from random expectation along a taxonomic lineage or across a subtree. It improves upon previous approaches by accounting for stochastic process, tree phylogeny, among-site rate variation, and alternative ancestral reconstructions. The method is validated using well-studied datasets, including MHC class I glycoproteins and carbonic anhydrase I.

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Researchers present a novel test for detecting excess radical amino-acid replacements in phylogenetic trees, indicative of positive Darwinian selection.

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  • File Format: PDF
  • File Size: 163 KB
  • Pages: 9
  • Language: EN
  • Total Downloads: 92
  • Last Updated: 3 weeks ago

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