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📊 Size: 2.32 MB
📄 Pages: 5 pages
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Researchers developed a method for the continuous amination of aryl/heteroaryl halides using aqueous ammonia in a Teflon AF-2400 tube-in-tube micro-flow reactor. This approach provides a green, economical, and safe protocol for synthesizing primary (hetero)arylamines, which are important chemical motifs used in the pharmaceutical, agrochemical, and materials industries. The reaction utilizes a gas-permeable membrane to allow ammonia to diffuse from aqueous ammonia into the reaction mixture, eliminating the need for toxic and explosive anhydrous ammonia. The optimized conditions enable high yields and productivity, making this method a promising alternative for industrial-scale synthesis.

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Researchers developed a method for the continuous amination of aryl/heteroaryl halides using aqueous ammonia in a Teflon AF-2400 tube-in-tube micro-flow...

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  • File Format: PDF
  • File Size: 2.32 MB
  • Pages: 5
  • Language: EN
  • Total Downloads: 118
  • Last Updated: 3 weeks ago

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