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PT Activates ERS To Fight NSCLC.pdf

s41598-017-08547-0.pdf
Preview of PT Activates ERS to Fight NSCLC
🔗 Source: nature.com
📊 Size: 2.98 MB
👤 Author: Zhiqiang Ma
⬇️ Downloads: 19

Summary

- Pterostilbene (PT), a natural compound, exhibits potent anticancer activity against non-small-cell lung cancer (NSCLC).
- PT's anti-NSCLC mechanism involves activating endoplasmic reticulum stress (ERS), leading to decreased cell viability and induced apoptosis in human PC9 and A549 NSCLC cell lines.
- PT treatment enhanced ERS signaling (p-PERK, IRE1, ATF4, CHOP), decreased cell migration and adhesion, and increased reactive oxygen species (ROS) generation and Caspase 3 activity.
- These effects were reversed by CHOP siRNA (inhibiting ERS signaling) and promoted by thapsigargin (a classical ERS inducer), both in vitro and in vivo.
- PT's anticancer activity in NSCLC is likely due to ERS activation, representing a novel therapeutic intervention for lung cancer.

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Description

Pterostilbene, a resveratrol analog, inhibits non-small-cell lung cancer by inducing endoplasmic reticulum stress.

Technical Information

  • File Format: PDF
  • File Size: 2.98 MB
  • Pages: 14
  • Language: EN
  • Author: Zhiqiang Ma
  • Total Downloads: 19
  • Last Updated: 4 weeks ago

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This PDF document about PT Activates ERS to Fight NSCLC provides comprehensive information and guidance. Whether you're a beginner or advanced user, this resource offers valuable insights into PT Activates ERS to Fight NSCLC.

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