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PU.1 Downregulation.pdf

6284-English-IranArze.pdf
Preview of PU.1 Downregulation
🔗 Source: iranarze.ir
📊 Size: 766 KB
📄 Pages: 7 pages
⬇️ Downloads: 70

Summary

PU.1 downregulation is linked to murine radiation-induced acute myeloid leukemia (AML), with decreased PU.1 expression observed in modified strains and radiation-induced chromosome 2 deletion and Sfpi1 point mutation leading to AML. Similar mechanisms, including heterozygous deletion of the SPI1 locus and mutation of the SPI1 upstream regulatory element, TP53 deletion, FLT3-ITD mutation, and AML1-ETO and PML-RARA translocations, are also observed in human primary AML, although they are rare events.

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Description

PU.1 downregulation is linked to murine radiation-induced acute myeloid leukemia (AML), with decreased PU.1 expression observed in modified strains and...

Technical Information

  • File Format: PDF
  • File Size: 766 KB
  • Pages: 7
  • Language: EN
  • Total Downloads: 70
  • Last Updated: 6 days ago

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