Re-Review Strategy For Acrylates Copolymers And Related Ingredients In Cosmetics.pdf

Background:

CIR published a Final Report on the Safety Assessment of Acrylates Copolymer and 33 Related Cosmetic Ingredients in 2002, concluding they were safe for use when formulated to avoid irritation.
Since then, 15+ years have passed, and 65 "add-on" ingredients need to be considered for inclusion in the re-review.
Additionally, CIR has published reports on similar ingredients, including: Ethyl Methacrylate, Crosslinked Alkyl Acrylates, Polymethyl Methacrylate/Methyl Methacrylate Crosspolymers, and Carbomers.

Re-Review Objectives:

Include 65 Add-on Ingredients: Determine whether these ingredients should be included in the re-review based on their definitions, functions, and frequency of use (FOU). A table listing these ingredients is provided for reference.
Consider Recent Reports: Evaluate the conclusions from the following reports to inform the re-review:
Ethyl Methacrylate (2002 amended report & 1995 original)
Crosslinked Alkyl Acrylates (2017)
Polymethyl Methacrylate, Methyl Methacrylate Crosspolymers, and Methyl Methacrylate/Glycol Dimethacrylate Crosspolymers (2011)
Carbomers (1982; reaffirmed in 2003)

Next Steps:

1. Panel Review: The CIR Expert Panel will review the provided information, including:
Definitions, functions, and FOU of all ingredients (original 34 plus 65 add-ons).
Minutes from previous deliberations on similar ingredients.
Relevant safety data and studies.
2. Discussion & Recommendations: The Panel will discuss each ingredient, considering its potential risks and benefits based on the available evidence. They will recommend whether each ingredient should be:

Included in the re-review.
Excluded from the re-review due to lack of evidence of harm or minimal risk.
3. Report & Recommendations: CIR will compile the Panel's recommendations and publish a report outlining the conclusions and rationale for each ingredient included or excluded from the re-review.