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Reviewer Report.pdf

40360_2023_654_ReviewerReport_V3_R2.pdf
Preview of Reviewer Report
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Summary

The manuscript describes the role of mitophagy in cisplatin-induced hearing loss. Cisplatin induces miR-34a, which downregulates DRP-1 RNA and increases autophagosome protein LC3, leading to increased oxidative stress. The study used HEI-OC1 cells and found that miR-34a mimic simulated cisplatin effects, while its inhibitor protected against cisplatin toxicity in vitro. However, the reviewer raised concerns about Western blot results, particularly the increase in LC3-II/I ratio, and the lack of functional studies in mice to determine hearing loss with miR-34a mimics or inhibitors. Minor comments included grammatical corrections, figure labeling, and typographical errors.

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Description

The manuscript describes the role of mitophagy in cisplatin-induced hearing loss.

Technical Information

  • File Format: PDF
  • File Size: 6 KB
  • Pages: 1
  • Language: EN
  • Total Downloads: 50
  • Last Updated: 7 days ago

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