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Reviewer Report.pdf

12885_2021_8894_ReviewerReport_V1_R1.pdf
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Summary

The authors investigated the impact of prior pertuzumab exposure on the efficacy of ado-trastuzumab (T-DM1) in patients with metastatic HER2-positive breast cancer. The study, a retrospective electronic chart review, found that prior exposure to pertuzumab did not affect survival outcomes. However, the reviewer argues that the conclusion is not supported by the data, which showed a lower objective clinical response rate in the pertuzumab-pre-treated group (14.3%) compared to the pertuzumab-naïve group (30%). The study's limitations include small sample sizes, potential bias due to differences in baseline patient characteristics, and limited statistical power to detect significant differences in progression-free survival (PFS). The reviewer suggests that the study's findings may actually indicate that prior pertuzumab exposure is associated with worse clinical outcomes.

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The authors investigated the impact of prior pertuzumab exposure on the efficacy of ado-trastuzumab (T-DM1) in patients with metastatic HER2-positive breast...

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  • File Format: PDF
  • File Size: 9 KB
  • Pages: 2
  • Language: EN
  • Total Downloads: 289
  • Last Updated: 1 month ago

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