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Reviewer Report - Paul Klatser.pdf

12879_2012_2285_ReviewerReport_V1_R1.pdf

Preview of Reviewer Report - Paul Klatser

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Summary

The research aimed to develop and validate dried blood spots (DBS) for quality assurance in syphilis serological assays, comparing DBS with plasma samples as reference in TPPA. However, the study's design and conclusions have several issues, including confusing terminology, unproven accuracy for diagnostic syphilis testing using DBS, and lack of reproducibility and repeatability data. The protocol for eluting antibodies from DBS is also cumbersome and may not be feasible in point-of-care testing (POCT) environments. Additionally, the discrepant analysis used to evaluate the performance of the diagnostic test is flawed and should not be used. The reviewer recommends major revisions to address these issues and provide clearer conclusions about the use of DBS for quality assurance purposes.

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Description

The research aimed to develop and validate dried blood spots (DBS) for quality assurance in syphilis serological assays, comparing DBS with plasma samples as...

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File Format: PDF
File Size: 4 KB
Pages: 2
Language: EN
Total Downloads: 125
Last Updated: 3 months ago

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