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🔗 Source: mi.fu-berlin.de
📊 Size: 242 KB
👤 Author: Alexander Bockmayr
⬇️ Downloads: 402

Summary

Metabolism adapts to changing environments and exhibits changes in enzyme activity even in constant environments, with significant alterations during the cell cycle. Gene products and enzymes catalyze reactions, and genes are regulated by gene and reaction products. A working hypothesis is that switching between pathways may improve overall efficiency, and this can be achieved by using multiple flux modes consecutively. The goal is to minimize the total time needed to produce a certain amount of output metabolites. This can be formulated as a non-linear mixed 0-1 optimization problem, which can be reformulated as a mixed 0-1 quadratic program. The approach involves modeling gene expression levels, sharing available enzymes, and optimizing cellular output. Biomass production in central carbon metabolism is used as an example, and optimal MinMode solutions are presented.

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Metabolism adapts to changing environments and exhibits changes in enzyme activity even in constant environments, with significant alterations during the cell...

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  • File Format: PDF
  • File Size: 242 KB
  • Pages: 5
  • Language: EN
  • Author: Alexander Bockmayr
  • Total Downloads: 402
  • Last Updated: 3 weeks ago

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