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The_pyriproxyfen_met Abolite_4_OH_PPF_dis Rupts_thyroid_hormon E_signaling_in_neura L_stem_cells_modifyi Ng_neurodevelopmenta L_genes_.pdf

The_pyriproxyfen_metabolite_4_OH_PPF_disrupts_thyroid_hormone_signaling_in_neural_stem_cells_modifying_neurodevelopmental_genes_affected_by_ZIKA_virus_infection.pdf

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📊 Size: 7.42 MB

👤 Author: Pieter Vancamp

⬇️ Downloads: 341

Summary

The pyriproxyfen metabolite, 4′–OH–PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. Researchers found that 4′–OH–PPF decreased thyroid hormone signaling and increased Musashi-1 expression, a protein necessary for ZIKV replication, in neural stem cells. Co-exposure to 4′–OH–PPF and ZIKV decreased viral replication but also dysregulated key genes in thyroid hormone signaling and neuroglial commitment, suggesting a synergistic block of transcriptional machinery. The study concludes that 4′–OH–PPF is a thyroid hormone antagonist that alters neural stem cell processes, potentially aggravating the microcephaly phenotype when combined with ZIKV infection.

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The pyriproxyfen metabolite, 4′–OH–PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus...

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File Format: PDF
File Size: 7.42 MB
Pages: 12
Language: EN
Author: Pieter Vancamp
Total Downloads: 341
Last Updated: 6 hours ago

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