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Tuberculosis Research.pdf

jci-130-134622.pdf
Preview of Tuberculosis Research
🔗 Source: ncbi.nlm.nih.gov
📊 Size: 4.55 MB
📄 Pages: 11 pages
⬇️ Downloads: 80

Summary

Tuberculosis (TB) patients have DNA hypermethylation of IL-2/STAT5, TNF/NF-κB, and IFN-γ signaling pathways, associated with decreased immune responsiveness, including reduced IFN-γ and proliferative capacity in response to M. tuberculosis-specific antigens and BCG, and increased expression of immune checkpoint inhibitors like PD-1, CTLA4, and TIM3.

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Description

Tuberculosis (TB) patients have DNA hypermethylation of IL-2/STAT5, TNF/NF-κB, and IFN-γ signaling pathways, associated with decreased immune responsiveness,...

Technical Information

  • File Format: PDF
  • File Size: 4.55 MB
  • Pages: 11
  • Language: EN
  • Total Downloads: 80
  • Last Updated: 1 week ago

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