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proteome-integral-solubility-alteration-assay-sensitivity.pdf
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🔗 Source: alliedacademies.org
📊 Size: 238 KB
👤 Author: Sudhansu Sekhar Patra
⬇️ Downloads: 85

Summary

Proteome Integral Solubility Alteration (PISA) assay increases analysis throughput for detecting changes in protein solubility, and thermal proteome profiling (TPP) tracks protein melting profiles to study protein interactions and stability. TPP can be applied in vitro, in situ, or in vivo, and has been used to investigate protein-protein and protein-metabolite interactions, as well as drug targets and off-targets. The technique enables a comprehensive view of the proteome in its natural setting, and can be used to study fundamental biological processes and their underlying mechanisms.

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Proteome Integral Solubility Alteration (PISA) assay increases analysis throughput for detecting changes in protein solubility, and thermal proteome profiling...

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  • File Format: PDF
  • File Size: 238 KB
  • Pages: 2
  • Language: EN
  • Author: Sudhansu Sekhar Patra
  • Total Downloads: 85
  • Last Updated: 12 hours ago

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