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Preprint.pdf

preprint.pdf
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🔗 Source: archive.gersteinlab.org
📊 Size: 3.02 MB
📄 Pages: 10 pages
⬇️ Downloads: 63

Summary

The Drosophila K10 gene product contains eight repeats of the octapeptide sequence SPNQQQHP, which is likely to be a DNA binding domain. The solution structure of a peptide composed of two SPNQQQHP units (HP2) was studied by NMR in aqueous trifluoroethanol solution. The results show that HP2 folds into two structural units, with the SPNQ part of each unit forming a turn structure and the C-terminal part showing some helical characteristics. A DNA footprinting study suggests that one SPNQQQHP unit spans four base pairs upon binding to A/T-rich sequences of DNA. The N-terminal turn is likely to provide a core that produces a more stable helical structure upon binding to DNA.

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Description

The Drosophila K10 gene product contains eight repeats of the octapeptide sequence SPNQQQHP, which is likely to be a DNA binding domain.

Technical Information

  • File Format: PDF
  • File Size: 3.02 MB
  • Pages: 10
  • Language: EN
  • Total Downloads: 63
  • Last Updated: 1 week ago

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