Depressed Elderly: Suicide Attempters Have Worse Depression And WML.pdf

Sachs-Ericcson-Suicide-AJGP.pdf
Preview of Depressed Elderly: Suicide Attempters Have Worse Depression and WML
🔗 Source: web.stanford.edu
📊 Size: 198 KB
👤 Author: Natalie Sachs-Ericsson Ph.D.
⬇️ Downloads: 26

Summary

Suicide attempters among depressed older patients exhibited more severe past and present depressive symptoms, higher current suicidal ideation, earlier age of onset, and greater lifetime depressive episodes compared to nonattempters. Baseline white-matter lesions (WML) were significantly higher in suicide attempters, and their WML growth increased more over time than in nonattempters. While WML predicted cognitive decline in older depressed patients, a history of suicide attempt was unrelated to baseline cognitive functioning or rates of cognitive decline. The study confirms that depression severity and WML are associated with suicide attempts in geriatric depressed patients, indicating that suicide attempts predict neurologic changes like WML progression. These neurobiological alterations may contribute to poorer long-term outcomes in older suicide attempters despite no direct cognitive impairment difference between groups.

Description

Older depressed patients who attempt suicide show greater depression severity, more white-matter lesions, and worse cognitive function compared to nonattempters. White-matter lesions may mediate the relationship between suicide attempts and cognitive impairment.

Technical Information

  • File Format: PDF
  • File Size: 198 KB
  • Pages: 11
  • Language: EN
  • Author: Natalie Sachs-Ericsson Ph.D.
  • Total Downloads: 26
  • Last Updated: 1 month ago

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