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NEL331112A02.pdf
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👤 Author: Notebook
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Researchers studied 19 girls with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, aged 3.7-19 years, to determine the relationship between androgenization in utero, measured by the second-to-fourth-digit ratio (2D:4D), and serum androgen concentrations. Despite proper hydrocortisone treatment, the girls had elevated androgen levels, with mean serum concentrations of testosterone, androstenedione, and dehydroepiandrostenedione sulphate (s-DHEA) being 150.21 ng/ml, 4.15 ng/ml, and 70.39 μg/dl, respectively. The mean 2D:4D ratio was 0.96, and analysis showed positive linear correlations between testosterone, s-DHEA, and 2D:4D ratio. The study suggests that the 2D:4D ratio may be a simple test to identify female CAH patients prone to excessive androgen secretion despite proper treatment, and that autonomization of adrenal androgen production in fetal life may contribute to elevated androgen levels in these patients.

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Researchers studied 19 girls with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, aged 3.7-19 years, to determine the relationship...

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  • File Format: PDF
  • File Size: 124 KB
  • Pages: 5
  • Language: EN
  • Author: Notebook
  • Total Downloads: 82
  • Last Updated: 1 month ago

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