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Http://medicinescien Ce.files.wordpress.c Om/2013/04/290.pdf

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Summary

Diabetic ketoacidosis (DKA) is a major acute diabetic complication that usually occurs in the context of total insulin deficiency, such as in insulin-dependent diabetes mellitus (IDDM). It is clinically defined by absolute insulin deficiency with hyperglycemia, increased lipolysis, increased ketone production, hyperketonemia, and acidosis. The incidence rate of DKA varies with definition, age, and sex, ranging from 4.6 to 8 per 1,000 diabetic persons per year, and is more common in young diabetic people and may be more common in women than men. Precipitating factors for DKA include infection, other acute illnesses, lack of diabetes education and training, non-compliance, poor self-care, inadequate glucose monitoring, psychological problems, and indeterminate causes. DKA requires hospitalization for treatment and is associated with significant morbidity and mortality, with mortality rates ranging from 9-14%. Prevention of DKA remains an important element in its management, and recognition of precipitating factors and appropriate instruction, awareness, and self-care can decrease the occurrence of this complication.

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Diabetic ketoacidosis (DKA) is a major acute diabetic complication that usually occurs in the context of total insulin deficiency, such as in insulin-dependent...

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