Vitamin C Model.pdf

The dynamic flow model proposes that an excess of oral ascorbate provides a steady flow of electrons through the body, restoring human physiology to the condition before the evolutionary loss of the ability to synthesize ascorbate. This model supports and extends the ideas of Linus Pauling, suggesting that high doses of vitamin C are essential to health. The model refutes the current low-dose hypothesis and resulting recommendations for dietary intakes.

Key points:

The dynamic flow model links Linus Pauling's megadose suggestions with other reported effects of massive doses for the treatment of disease.
The model proposes a mechanism by which human physiology can compensate for losing the ability to synthesize vitamin C.
The low-dose hypothesis, which forms the basis for the RDA, is that humans require only a few milligrams of ascorbate each day.
The megadose hypothesis suggests that people need one or more grams of ascorbate per day.
The NIH pharmacokinetic results show that the body excretes ascorbate rapidly at high intake levels, with a half-life of about half an hour.
The plasma half-life of ascorbate is widely reported to be between 8-40 days, but this applies only to periods of deficient intake.
The NIH data shows that blood plasma levels are not saturated at 70 μM/L, as previously claimed, but rather at much higher levels.
Bioavailability is a relative measure that compares the oral absorption of a substance to an equal injected dose, and the NIH claimed that the bioavailability of ascorbate is complete at an intake of 200 mg.