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Vitamin D Deficiency And All-Cause Mortality: A Systematic Review And Meta-Analysis.pdf

1471-2458-13-679.pdf
Preview of Vitamin D Deficiency and All-Cause Mortality: A Systematic Review and Meta-Analysis
🔗 Source: biomedcentral.com
📊 Size: 493 KB
📄 Pages: 9 pages
⬇️ Downloads: 58

Summary

A Systematic Review

## Background
The study investigates the hypothesis that low vitamin D levels contribute to higher premature mortality rates in Glasgow compared to Liverpool and Manchester, with a 30% difference observed in all-cause mortality under 65 years of age.

## Methods
A systematic review and meta-analysis were conducted following PRISMA guidelines. The search included studies from Medline, EMBASE, Web of Science, the Cochrane Library, and grey literature sources until February 2012. Nine studies with a total of 24,297 participants (5,324 deaths) were included.

## Results
- A significant inverse association was found between low vitamin D levels and all-cause mortality (hazard ratio [HR] 1.19, 95% CI 1.12-1.27).
- Age-stratified analysis revealed a stronger association in older participants (HR 1.25, 95% CI 1.14-1.36) compared to younger ones (HR 1.12, 95% CI 1.01-1.24).

## Conclusions
Low vitamin D status is associated with increased all-cause mortality, but the risk varies by age. Further research is needed to confirm these findings, especially in younger adults, and to account for potential confounders or reverse causality.

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Description

A systematic review and meta-analysis examining the link between vitamin D levels and all-cause mortality in individuals under 65, showing a significant inverse association (HR 1.19) between low vitamin D and premature death.

Technical Information

  • File Format: PDF
  • File Size: 493 KB
  • Pages: 9
  • Language: EN
  • Total Downloads: 58
  • Last Updated: 2 weeks ago

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Vitamin guideVitamin tutorialDeficiency guideDeficiency tutorialAll-Cause guideAll-Cause tutorialMortality: guideMortality: tutorialSystematic guideSystematic tutorialReview guideReview tutorialMeta-Analysis guideMeta-Analysis tutorial

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