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🔗 Source: nature.com
📊 Size: 5.03 MB
👤 Author: Alexander C. Dowell
⬇️ Downloads: 206

Summary

SARS-CoV-2 infection is generally mild or asymptomatic in children, and a study comparing antibody and cellular immunity in children (aged 3–11 years) and adults found that children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection. Antibody responses against spike protein were high in children, and seroconversion boosted responses against seasonal Beta-coronaviruses. Neutralization of viral variants was comparable between children and adults, and spike-specific T cell responses were more than twice as high in children. Children retained antibody and cellular responses 6 months after infection, whereas relative waning occurred in adults. These findings provide insight into the relative clinical protection that occurs in most children and might help guide the design of pediatric vaccination regimens.

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SARS-CoV-2 infection is generally mild or asymptomatic in children, and a study comparing antibody and cellular immunity in children (aged 3–11 years) and...

Technical Information

  • File Format: PDF
  • File Size: 5.03 MB
  • Pages: 19
  • Language: EN
  • Author: Alexander C. Dowell
  • Total Downloads: 206
  • Last Updated: 11 hours ago

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