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BIORXIV-2017-228783v1-Pineda Torra.pdf
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🔗 Source: discovery.ucl.ac.uk
📊 Size: 3.16 MB
📄 Pages: 27 pages
⬇️ Downloads: 111

Summary

Disrupting myeloid-specific LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Mice with a Ser-to-Ala mutation in myeloid cells exhibit increased atherosclerotic plaque burden, smaller necrotic cores, and thinner fibrous caps. LXRα-S196A induces expression of proliferation-promoting factors, including FoxM1, and increases macrophage efferocytosis, explaining the reduced necrotic cores. The macrophage transcriptome promoted by LXRα-S196A is distinct from that revealed by LXR ligand activation, highlighting the importance of LXRα phosphorylation in atherosclerotic plaque development.

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Description

Disrupting myeloid-specific LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

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  • File Format: PDF
  • File Size: 3.16 MB
  • Pages: 27
  • Language: EN
  • Total Downloads: 111
  • Last Updated: 1 week ago

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