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WRAP_journal.pgen.1005046.pdf
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🔗 Source: wrap.warwick.ac.uk
📊 Size: 4.89 MB
👤 Author: Ruben A. T. Mars, Pierre Nicolas, Mariano Ciccolini, Ewoud Reilman, Alexander Reder, Marc Schaffer,
⬇️ Downloads: 94

Summary

Researchers found that a small regulatory RNA (sRNA) called RnaC/S1022 in the bacterium Bacillus subtilis can induce heterogeneity in growth rates by increasing cell-to-cell variation in the levels of the transcriptional regulator AbrB. This variation is induced post-transcriptionally and is not observed at the abrB promoter level. The study suggests that induction of protein expression noise could be a new general aspect of sRNA regulation, and that the resulting subpopulations of fast- and slow-growing B. subtilis cells may reflect a bet-hedging strategy for enhanced survival of unfavorable conditions.

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Researchers found that a small regulatory RNA (sRNA) called RnaC/S1022 in the bacterium Bacillus subtilis can induce heterogeneity in growth rates by...

Technical Information

  • File Format: PDF
  • File Size: 4.89 MB
  • Pages: 28
  • Language: EN
  • Author: Ruben A. T. Mars, Pierre Nicolas, Mariano Ciccolini, Ewoud Reilman, Alexander Reder, Marc Schaffer,
  • Total Downloads: 94
  • Last Updated: 7 days ago

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