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NEL290508A17.pdf
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📊 Size: 258 KB
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Chronic low-dose L-NAME treatment in borderline hypertensive rats (BHR) induced sustained blood pressure elevation and left ventricular hypertrophy, associated with decreased nitric oxide synthase (NOS) activity in the left ventricle, but not in the aorta. In contrast, Wistar rats showed improved NOS activity in both the left ventricle and aorta. The treatment had no effect on NOS activity in the hypothalamus of either group. Additionally, L-NAME treatment improved vascular function in Wistar rats, but not in BHR, suggesting that NOS/NO feedback regulation works differently under conditions of normotension and prehypertension.

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Chronic low-dose L-NAME treatment in borderline hypertensive rats (BHR) induced sustained blood pressure elevation and left ventricular hypertrophy, associated...

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  • File Format: PDF
  • File Size: 258 KB
  • Pages: 6
  • Language: EN
  • Total Downloads: 66
  • Last Updated: 4 weeks ago

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