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NEL31S210A01.pdf
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🔗 Source: nel.edu
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👤 Author: Notebook
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N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole, is metabolized by rat hepatic microsomes predominantly to o-anisidine. The major microsomal enzymes participating in this process are CYP2C, followed by CYP2E1, 2D, and 2A. Recombinant rat CYP enzymes, particularly CYP2C11 and 2E1, are the most efficient in metabolizing N-(2-methoxyphenyl)hydroxylamine to o-anisidine. The study suggests that the formation and further conversion of N-(2-methoxyphenyl)hydroxylamine play a key role in the carcinogenic effects of o-anisidine and o-nitroanisole.

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N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole, is metabolized by rat...

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  • File Format: PDF
  • File Size: 233 KB
  • Pages: 10
  • Language: EN
  • Author: Notebook
  • Total Downloads: 81
  • Last Updated: 1 week ago

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