Home › Categories › Science & Nature› Gene Delivery Nanoparticles

Gene Delivery Nanoparticles.pdf

Nademi_Yousef_202101_PhD.pdf
Preview of Gene Delivery Nanoparticles
🔗 Source: era.library.ualberta.ca
📊 Size: 16.36 MB
👤 Author: gracet
⬇️ Downloads: 177

Summary

This dissertation investigates membrane penetration of polynucleotide nanoparticles (NPs) using computational approaches and experiments, focusing on polymer-polynucleotide NPs formed by polyethylenimine (PEI) and siRNA molecules. The study explores the stability and configurational changes of NPs during penetration into zwitterionic and anionic membranes, finding that hydrogen bond formation between PEIs and the membrane does not lead to instability, but instead, the NP adopts a "self-protecting" configuration. The results also show that lipid substitution on PEIs enhances NP stability, and machine learning algorithms can predict cellular uptake of hydrophobically modified PEI/siRNA NPs into cancer cell lines, with critical descriptors including PEI-to-siRNA weight ratio and type of hydrophobic substitution.

Download File

Description

This dissertation investigates membrane penetration of polynucleotide nanoparticles (NPs) using computational approaches and experiments, focusing on...

Technical Information

  • File Format: PDF
  • File Size: 16.36 MB
  • Pages: 284
  • Language: EN
  • Author: gracet
  • Total Downloads: 177
  • Last Updated: 3 weeks ago

Document Overview

This PDF document about Gene Delivery Nanoparticles provides comprehensive information and guidance. Whether you're a beginner or advanced user, this resource offers valuable insights into Gene Delivery Nanoparticles.

Related Topics

If you're interested in Gene Delivery Nanoparticles, you might also want to explore:

Gene guideGene tutorialDelivery guideDelivery tutorialNanoparticles guideNanoparticles tutorial

Related Categories

Business & Finance
41204 documents
Education & Learning
22711 documents
Health & Wellness
8956 documents
Technology
4783 documents

Related Documents

Preview of Green Version
PDF file

Green Version

1.13 MBEN23 pages
Microcell-mediated chromosome transfer (MMCT) is a technique that transfers a chromosome from donor cells to recipient cells, used for gene delivery...
Download
Preview of Gene
PDF file

Gene

390 KBJoan UlmerEN3 pages
The Nonprofit Center at La Salle University's CLEAR Circles provide a space for nonprofit leaders to share experiences and advice, with the goal of...
Download
Preview of Nanoparticles for Liver Fibrosis
PDF file

Nanoparticles for Liver Fibrosis

2.44 MBYANGEN10 pages
Nanoparticles are being developed to target hepatic stellate cells (HSC) for the treatment of liver fibrosis, a scarring process that can progress to...
Download
Preview of Gene Therapy
PDF file

Gene Therapy

668 KBAlain FischerEN6 pages
Gene therapy has become a reality, achieving clinical benefits in limited medical conditions, including inherited immune system disorders,...
Download
Preview of delivery laboratorio
PDF file

delivery laboratorio

1.14 MBcieu1NL21 pages
DELIVERY DE EXÁMENES DE LABORATORIO CLÍNICO EN LA PROVINCIA DE HUANCAYO" door Balbín Diana, Gómez Huamán Nilda, Palomino Trigos Yenny, Quinte Gómez...
Download

Download Gene Delivery Nanoparticles eBooks for free and learn more about Gene Delivery Nanoparticles. These books contain exercises and tutorials to improve your practical skills, at all levels!

Not satisfied with this document? We have related documents to Gene Delivery Nanoparticles, try searching with similar keywords: Gene Delivery Nanoparticles, 11.4 Gene Linkage And Gene Maps Answers, Gene Ammons Gene Ammons And Friends At Montreux 19, Gene Ammons The Gene Ammons Story The 78 Era 1992 , Gene By Gene Ltd, Gene Harris The Three Sounds Gene Harris Of The Th, Gene Pitney This Is Gene Pitney 1966 , gene procaryotes gene eucaryot

You can download PDF versions of the user's guide, manuals and ebooks about Gene Delivery Nanoparticles, you can also find and download for free A free online manual (notices) with beginner and intermediate, Downloads Documentation, You can download PDF files (or DOC and PPT) about Gene Delivery Nanoparticles for free, but please respect copyrighted ebooks.