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Http://scienceofmedi Cine.files.wordpress .com/2013/04/75.pdf

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Summary

The priming of tumor-antigen-specific T cells is crucial for anti-tumor immune responses, but their fate during tumor progression is unknown. Researchers transferred naive CD4+ T cells specific for a tumor antigen into tumor-bearing mice and found that these cells underwent transient clonal expansion, phenotypic changes, and diminished response to peptide antigen. The development of antigen-specific T cell anergy occurred early in tumor progression, suggesting that tolerance to tumor antigens may hinder therapeutic vaccination.

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Description

The priming of tumor-antigen-specific T cells is crucial for anti-tumor immune responses, but their fate during tumor progression is unknown.

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  • File Size: 266 KB
  • Pages: 6
  • Language: EN
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