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Hilaire2016.pdf
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Summary

Proton therapy monitoring by Compton imaging is influenced by the large energy spectrum of prompt-γ radiation, affecting the quality of reconstructed images. The impact of factors such as volume attenuation, spatial and energy resolutions, and noise from other particles is significant. This study investigates the influence of the prompt-γ energy spectrum on reconstructed images using Monte Carlo simulations and Compton imaging with a statistical MLEM method. The results show that incomplete absorption of high-energy photons prevents observation of prompt-γ distributions at specific energies, leading to blurred images and smoothed distal slopes of 1D profiles. Selecting events with almost complete energy deposition improves image quality, emphasizing the importance of detector choice. A method to estimate the range of the prompt-γ profile is proposed, relying on two parameters estimated using a learning approach, allowing detection of few millimeter shifts in the profiles.

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Proton therapy monitoring by Compton imaging is influenced by the large energy spectrum of prompt-γ radiation, affecting the quality of reconstructed images.

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