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Ladda Ner Fulltext (pdf) Av Mesenchymal Stromal Cells Supportendothelial Cell Interactions In Anintramuscular Islet Transplantat.pdf

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Preview of Ladda ner fulltext (pdf) av Mesenchymal stromal cells supportendothelial cell interactions in anintramuscular islet transplantat
🔗 Source: uu.diva-portal.org
📊 Size: 1.9 MB
👤 Author: Moa Fransson
⬇️ Downloads: 127

Summary

Mesenchymal stromal cells (MSC) support endothelial cell interactions in an intramuscular islet transplantation model. Human islets coated with luciferase-GFP transduced human MSC were transplanted to the abdomen muscle tissue of NOD-scid ILR2γnull mice. The MSC reduced fibrotic encapsulation and facilitated endothelial cell interactions, with decreased αSMA expressing fibrotic tissue and increased human islet endothelial cell migration forming chimeric blood vessels with recipient endothelial cells. MSC also interacted with infiltrating macrophages, contributing to reduced fibrosis and increased islet endothelial cell migration.

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Description

Mesenchymal stromal cells (MSC) support endothelial cell interactions in an intramuscular islet transplantation model.

Technical Information

  • File Format: PDF
  • File Size: 1.9 MB
  • Pages: 12
  • Language: EN
  • Author: Moa Fransson
  • Total Downloads: 127
  • Last Updated: 3 weeks ago

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