MRNA Boosters.pdf

2022.02.03.479037v1.full.pdf
Preview of mRNA Boosters
🔗 Source: biorxiv.org
📊 Size: 25.09 MB
📄 Pages: 51 pages
⬇️ Downloads: 104

Summary

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron. Neutralizing antibody titers against D614G and Omicron increased after boost, with 70-80% of spike-specific B cells cross-reactive against both WA1 and Omicron, and significant control of virus replication in lower airways observed after either boost, suggesting an Omicron boost may not provide greater immunity or protection compared to a boost with the current mRNA-1273 vaccine.

Description

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron.

Technical Information

  • File Format: PDF
  • File Size: 25.09 MB
  • Pages: 51
  • Language: EN
  • Total Downloads: 104
  • Last Updated: 1 month ago

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