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Nicotinic Acid Upregulates Intestinal Antimicrobial Peptides Via Manipulating The Histone Acetylation Modification To Enhance Th.pdf

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Summary

Nicotinic acid (NA) alleviates clinical symptoms, intestinal morphological damage, and inflammation in weaned piglets infected with Escherichia coli (ETEC) K88 by enhancing endogenous antimicrobial peptides expression through manipulating histone acetylation modification. NA reduces ETEC K88 in spleen and liver, alleviates inflammatory cytokine expression, and increases antimicrobial peptides and secretory immunoglobulin A (SIgA) in intestines. NA also increases microflora diversity and reduces Bacteroidetes, Bacteroidales, and Bacteroidia abundance. The study suggests NA as a potential feed additive to improve disease resistance in weaned piglets.

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Nicotinic acid (NA) alleviates clinical symptoms, intestinal morphological damage, and inflammation in weaned piglets infected with Escherichia coli (ETEC) K88...

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  • File Format: PDF
  • File Size: 3.96 MB
  • Pages: 27
  • Language: EN
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