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2004_Evans_etal_PNAS.pdf

🔗 Source: heinrichlab.bme.ucdavis.edu

📊 Size: 451 KB

📄 Pages: 6 pages

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Summary

Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond were observed using a sensitive force probe to test the leukocyte adhesion bond P-selectin glycoprotein ligand 1 (PSGL-1)–P-selectin. The bond strength increased linearly with each 10-fold increase in the rate of force application from 300 to 30,000 pN·sec, implying a single pathway for failure. However, the strength and lifetime of PSGL-1–P-selectin bonds dropped anomalously when loaded below 300 pN·sec, demonstrating unexpectedly faster dissociation and a possible second pathway for failure. A new "jump-ramp" mode of force spectroscopy was used to show that the PSGL-1–P-selectin bond behaves as a mechanochemical switch where force history selects between two dissociation pathways with markedly different properties.

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Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond were observed using a sensitive force probe to test the...

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File Format: PDF
File Size: 451 KB
Pages: 6
Language: EN
Total Downloads: 85
Last Updated: 7 days ago

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