How Do Small Single-domain Proteins Fold?.pdf

1998_FoldDes.pdf
Preview of How do small single-domain proteins fold?
🔗 Source: web.archive.org
📊 Size: 359 KB
📄 Pages: 11 pages
⬇️ Downloads: 115

Summary

Small single-domain proteins fold with simple two-state kinetics, showing wide variation in folding rates from microseconds to seconds, and stable intermediates are not a prerequisite for fast folding, which may in fact be hindered by kinetic traps. Recent studies allow for the search of trends to better understand protein folding, with data summarized for proteins folding with two-state kinetics, compared to those folding via stable intermediates and dimeric proteins, revealing general trends and correlations between structural and thermodynamic properties and folding kinetics.

Description

Small single-domain proteins fold with simple two-state kinetics, showing wide variation in folding rates from microseconds to seconds, and stable...

Technical Information

  • File Format: PDF
  • File Size: 359 KB
  • Pages: 11
  • Language: EN
  • Total Downloads: 115
  • Last Updated: 3 weeks ago

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