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VS-6766 Inhibitor.pdf

Pachter-Verastem-AACR-NCI-EORTC-meeting-Oct-2021-FINAL.pdf
Preview of VS-6766 Inhibitor
🔗 Source: verastem.com
📊 Size: 961 KB
👤 Author: McCullough, John
⬇️ Downloads: 112

Summary

VS-6766 is a dual RAF/MEK inhibitor that inhibits both MEK and RAF kinase activities, providing an advantage over MEK inhibitors by not inducing MEK phosphorylation. It inhibits ERK signaling more completely and shows strong single-agent anti-tumor activity across various solid tumor models, including KRAS-mutant NSCLC, ovarian, pancreatic, and colorectal cancer. VS-6766 demonstrates potent inhibition of cell proliferation across multiple MAPK pathway alterations and solid tumor indications.

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Description

VS-6766 is a dual RAF/MEK inhibitor that inhibits both MEK and RAF kinase activities, providing an advantage over MEK inhibitors by not inducing MEK...

Technical Information

  • File Format: PDF
  • File Size: 961 KB
  • Pages: 7
  • Language: EN
  • Author: McCullough, John
  • Total Downloads: 112
  • Last Updated: 7 days ago

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This PDF document about VS-6766 Inhibitor provides comprehensive information and guidance. Whether you're a beginner or advanced user, this resource offers valuable insights into VS-6766 Inhibitor.

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