Ladda Ner Fulltext (pdf) Av Boosting CAR T-cell Responses In Lymphoma By Simultaneous Targeting Of CD40/4-1BB Using Oncolytic Vi.pdf

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Preview of Ladda ner fulltext (pdf) av Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic vi
🔗 Source: uu.diva-portal.org
📊 Size: 1.2 MB
👤 Author: Jessica Wenthe
⬇️ Downloads: 98

Summary

Researchers investigated the therapeutic potential of LOAd703, an oncolytic adenovirus, in human B-cell lymphoma models, alone or in combination with CAR T-cell therapy. LOAd703 infected and replicated in B-cell lymphoma cell lines, inducing an enhanced immunogenic profile and upregulating co-stimulatory molecules. CAR T-cell functionality was boosted by stimulation with lymphoma cells infected with LOAd703, demonstrated by increased release of IFN-γ and granzyme B, and enhanced lymphoma cell killing in vitro and in vivo. LOAd703-infected lymphoma cells also upregulated chemokine secretion, leading to enhanced CAR T-cell migration. The study suggests that immunostimulatory LOAd703 therapy may improve CAR T-cell therapy in B-cell lymphoma.

Description

Researchers investigated the therapeutic potential of LOAd703, an oncolytic adenovirus, in human B-cell lymphoma models, alone or in combination with CAR...

Technical Information

  • File Format: PDF
  • File Size: 1.2 MB
  • Pages: 15
  • Language: EN
  • Author: Jessica Wenthe
  • Total Downloads: 98
  • Last Updated: 1 month ago

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