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Supplementary Information.pdf

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🔗 Source: static-content.springer.com
📊 Size: 489 KB
📄 Pages: 10 pages
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Summary

STING agonist delivery by tumor-penetrating PEG-lipid nanodiscs primes robust anti-cancer immunity. Researchers used coarse-grain molecular dynamics simulations to model the transport of LNDs versus liposomes through small pores, finding that LNDs can deform and enter pores smaller than their equilibrium diameter, while liposomes cannot. An analytical model was developed to capture the essential elements of LND translocation through pores, considering the free energy of translocation and the force necessary to overcome the energy barrier. The model suggests that LNDs can translocate through pores with forces on the order of pNs, which are typical of biological forces, and that interstitial flow in tumors can provide sufficient forces to drag LNDs through constricted apertures in the ECM.

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Description

STING agonist delivery by tumor-penetrating PEG-lipid nanodiscs primes robust anti-cancer immunity.

Technical Information

  • File Format: PDF
  • File Size: 489 KB
  • Pages: 10
  • Language: EN
  • Total Downloads: 68
  • Last Updated: 1 month ago

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