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Télécharger Le Fichier.pdf

fcell-08-624213.pdf
Preview of Télécharger le fichier
🔗 Source: amu.hal.science
📊 Size: 1.33 MB
👤 Author: Cynthia Arroyo Portilla, Julie Tomas, Jean-Pierre Gorvel, Hugues Lelouard
⬇️ Downloads: 183

Summary

This article reviews recent advances on intestinal macrophages in several species, focusing on their specificity and functions. Macrophages are professional phagocytic cells that play a central role in maintaining homeostasis through pathogen killing, efferocytosis, and tissue shaping, repair, and remodeling. The gut displays several anatomic and functional compartments with large pools of diversified macrophage populations. The review highlights the great plasticity of macrophages, which become adapted to perform particular functions shaped by their microenvironment, giving rise to high population diversity. Phagocytosis, an ancient process, has evolved from a nutritional function to key roles in homeostasis, including apoptotic cell removal, tissue remodeling, and immune defense. The article discusses the evolution of phagocytosis across different eukaryotic species, the diversity of proteins associated with phagosomes, and the role of macrophages in intestinal immunity, microbiota, and dietary antigens.

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Description

This article reviews recent advances on intestinal macrophages in several species, focusing on their specificity and functions.

Technical Information

  • File Format: PDF
  • File Size: 1.33 MB
  • Pages: 20
  • Language: EN
  • Author: Cynthia Arroyo Portilla, Julie Tomas, Jean-Pierre Gorvel, Hugues Lelouard
  • Total Downloads: 183
  • Last Updated: 1 week ago

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