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Web Archive Capture PDF (387.9 KB).pdf

SatSept128.pdf

Preview of Web Archive Capture PDF (387.9 kB)

🔗 Source: web.archive.org

📊 Size: 378 KB

👤 Author: Arend

⬇️ Downloads: 130

Summary

Germline-encoded anti-A-reactive IgM arises from growth-dependent and aberrant O-GalNAc glycosylations, with the target being a trans-species developmental antigen that signifies malignancy when accumulating in non-developmental tissues. This anti-A antibody is serologically identical to the human innate anti-A isoagglutinin and is complementary to mammalian O-GalNAc glycan-bearing ovarian glycolipids. The antibody's development is not enhanced in mice subjected to ovariectomy prior to puberty, and its expression is related to early growth-dependent O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion. The anti-A reactivity is also associated with cross-reactive anti-Tn antibody, which may function as a growth regulator and initiate growth inhibition through enzyme-substrate competition.

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Description

Germline-encoded anti-A-reactive IgM arises from growth-dependent and aberrant O-GalNAc glycosylations, with the target being a trans-species developmental...

Technical Information

File Format: PDF
File Size: 378 KB
Pages: 22
Language: EN
Author: Arend
Total Downloads: 130
Last Updated: 3 weeks ago

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