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Aristolochic Acid Activation.pdf

NEL32S111A07.pdf
Preview of Aristolochic Acid Activation
🔗 Source: nel.edu
📊 Size: 438 KB
👤 Author: Notebook
⬇️ Downloads: 151

Summary

Aristolochic acid I (AAI) is more toxic than its demethoxylated derivative aristolochic acid II (AAII) due to differences in enzymatic conversion, with human NAD(P)H:quinone oxidoreductase (NQO1) being more effective in activating AAI than AAII, and phase II enzymes such as sulfotransferases and N-acetyltransferases not stimulating the bioactivation of AAs, but rather inhibiting NQO1-mediated bioactivation of AAII.

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Description

Aristolochic acid I (AAI) is more toxic than its demethoxylated derivative aristolochic acid II (AAII) due to differences in enzymatic conversion, with human...

Technical Information

  • File Format: PDF
  • File Size: 438 KB
  • Pages: 14
  • Language: EN
  • Author: Notebook
  • Total Downloads: 151
  • Last Updated: 1 week ago

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