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ASXL1 Mutations Promote Myeloid Transformation Through Loss Of PRC2-mediated Gene Repression..pdf

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Preview of ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
🔗 Source: lafavelab.org
📊 Size: 1.63 MB
👤 Author: Omar Abdel-Wahab; Mazhar Adli; LindsaynbspM. LaFave; Jie Gao; Todd Hricik; AlannbspH. Shih; Suveg Pa
⬇️ Downloads: 136

Summary

ASXL1 mutations occur in 15%-25% of patients with myelodysplastic syndrome and 10%-15% of patients with myeloproliferative neoplasms and acute myeloid leukemia, and are associated with adverse outcomes. These mutations result in loss of polycomb repressive complex 2 (PRC2)-mediated histone H3 lysine 27 (H3K27) tri-methylation, leading to loss of repression of target genes, including the posterior HOXA cluster, which contributes to myeloid transformation. ASXL1 associates with the PRC2 complex and loss of ASXL1 collaborates with NRASG12D to promote myeloid leukemogenesis.

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Description

ASXL1 mutations occur in 15%-25% of patients with myelodysplastic syndrome and 10%-15% of patients with myeloproliferative neoplasms and acute myeloid...

Technical Information

  • File Format: PDF
  • File Size: 1.63 MB
  • Pages: 14
  • Language: EN
  • Author: Omar Abdel-Wahab; Mazhar Adli; LindsaynbspM. LaFave; Jie Gao; Todd Hricik; AlannbspH. Shih; Suveg Pa
  • Total Downloads: 136
  • Last Updated: 5 days ago

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