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Bovine Lethal Syndrome.pdf

345-2022-08-12-Altered_endothelin-2_cause_lethal_bovine_syndrome.pdf
Preview of Bovine Lethal Syndrome
🔗 Source: ucm.es
📊 Size: 4.29 MB
📄 Pages: 18 pages
⬇️ Downloads: 171

Summary

A novel missense variant (c.149G>A|p.Cys50Tyr) in the endothelin-2 (EDN2) gene causes a growth and respiratory lethal syndrome in bovine, characterized by severe growth retardation, respiratory alterations, and juvenile lethality. Genome-wide association study and whole-genome re-sequencing identified the causative variant, which is predicted to be damaging to the structure and function of the edn2 protein. The identification of the variant enables the development of a diagnostic genetic test, allowing for efficient design of matings to reduce the risk of the syndrome.

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Description

A novel missense variant (c.149G>A|p.Cys50Tyr) in the endothelin-2 (EDN2) gene causes a growth and respiratory lethal syndrome in bovine, characterized by...

Technical Information

  • File Format: PDF
  • File Size: 4.29 MB
  • Pages: 18
  • Language: EN
  • Total Downloads: 171
  • Last Updated: 3 weeks ago

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