Organophosphorus Inhibitors.pdf

MMSL_2015_4_6_WWW.pdf
Preview of Organophosphorus Inhibitors
🔗 Source: mmsl.cz
📊 Size: 520 KB
👤 Author: Georg Petroianu
⬇️ Downloads: 124

Summary

The history of organophosphorus cholinesterase inhibitors and reactivators involves several key scientists, including Jean Louis Lassaigne, who made the analogy between sulphovinic and phosphovinic acids, and Jules Pelouze, who synthesized phosphovinic acid. Franz Anton Voegeli synthesized triethyl phosphate (TEP), the first organophosphate, under the supervision of Gustav Magnus. Wladimir Petrovich Moshnin and Philippe de Clermont co-developed the first organophosphate acetylcholinesterase inhibitor, tetraethyl pyrophosphate (TEPP). Gerhard Schrader synthesized tabun-like organophosphonate compounds, and Irwin B. Wilson and Sara Ginsburg developed the first pyridinium aldoxime reactivator, 2-PAM (pralidoxime), which can reactivate cholinesterase inhibited by organophosphates.

Description

The history of organophosphorus cholinesterase inhibitors and reactivators involves several key scientists, including Jean Louis Lassaigne, who made the...

Technical Information

  • File Format: PDF
  • File Size: 520 KB
  • Pages: 4
  • Language: EN
  • Author: Georg Petroianu
  • Total Downloads: 124
  • Last Updated: 1 week ago

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