Télécharger Le Fichier.pdf

Manuscript PIIINP EPHESUS.pdf
Preview of Télécharger le fichier
🔗 Source: hal.univ-lorraine.fr
📊 Size: 1019 KB
👤 Author: Susan Stienen, Patrick Rossignol, Antonio Barros, Nicolas Girerd, Bertram Pitt, Faiez Zannad, Joao P
⬇️ Downloads: 126

Summary

Determinants of anti-fibrotic response to mineralocorticoid receptor antagonist therapy were identified in patients with myocardial infarction. Female sex, eplerenone, reperfusion therapy, low potassium, and high levels of PIIINP and PINP predicted a decrease in PIIINP. Patients with higher PIIINP levels at randomization had a better response to eplerenone, suggesting that higher PIIINP levels may help identify patients prone to an anti-fibrotic response. External validation showed good discrimination, and decreased PIIINP was associated with a lower rate of cardiovascular death or hospitalization.

Description

Determinants of anti-fibrotic response to mineralocorticoid receptor antagonist therapy were identified in patients with myocardial infarction.

Technical Information

  • File Format: PDF
  • File Size: 1019 KB
  • Pages: 30
  • Language: EN
  • Author: Susan Stienen, Patrick Rossignol, Antonio Barros, Nicolas Girerd, Bertram Pitt, Faiez Zannad, Joao P
  • Total Downloads: 126
  • Last Updated: 3 months ago

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