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Intestinal Barrier Function.pdf

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Preview of Intestinal Barrier Function
🔗 Source: scientificarchives.com
📊 Size: 530 KB
👤 Author: Siddhartha S Ghosh
⬇️ Downloads: 229

Summary

High fat, high cholesterol Western-type diets induce obesity, metabolic syndrome, and diseases like Type 2 Diabetes and atherosclerosis by disrupting the intestinal barrier function, leading to the translocation of gut bacteria-derived lipopolysaccharide into systemic circulation, causing chronic inflammation. The intestinal barrier consists of multiple layers, including luminal alkaline phosphatase, the mucus layer, tight junctions, and anti-bacterial proteins. Disruption of these layers by Western-type diets can be targeted to prevent metabolic diseases, with intestinal alkaline phosphatase emerging as a key component in maintaining the balance between the host and the luminal microbial environment.

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Description

High fat, high cholesterol Western-type diets induce obesity, metabolic syndrome, and diseases like Type 2 Diabetes and atherosclerosis by disrupting the...

Technical Information

  • File Format: PDF
  • File Size: 530 KB
  • Pages: 5
  • Language: EN
  • Author: Siddhartha S Ghosh
  • Total Downloads: 229
  • Last Updated: 17 hours ago

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