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Lipase Modulation Of Macrophage Cholesterol Efflux.pdf

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Preview of Lipase Modulation of Macrophage Cholesterol Efflux
🔗 Source: research.library.mun.ca
📊 Size: 1.12 MB
👤 Author: Jenika Marshall
⬇️ Downloads: 362

Summary

Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and may promote atherosclerosis progression. Free fatty acids (FFA) liberated by LPL modulate macrophage cholesterol efflux via Akt activation in vitro. FFA components, particularly palmitoleate, increase Akt phosphorylation, which inhibits cholesterol efflux to apolipoprotein A-I. Blocking Akt phosphorylation restores cholesterol efflux levels, supporting a negative role for LPL in macrophage lipid accumulation and atherogenesis.

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Description

Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and may promote atherosclerosis progression.

Technical Information

  • File Format: PDF
  • File Size: 1.12 MB
  • Pages: 109
  • Language: EN
  • Author: Jenika Marshall
  • Total Downloads: 362
  • Last Updated: 16 hours ago

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Lipase guideLipase tutorialModulation guideModulation tutorialMacrophage guideMacrophage tutorialCholesterol guideCholesterol tutorialEfflux guideEfflux tutorial

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