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Peer Review File.pdf

41467_2019_10689_MOESM2_ESM.pdf

🔗 Source: static-content.springer.com

📊 Size: 260 KB

👤 Author: Michael Rosch

⬇️ Downloads: 105

Summary

Reviewers' comments on a study about CDKL5 deficiency disorder (CDD) and its relation to autism spectrum disorders (ASD). The study shows that loss of CDKL5 in GABAergic neurons results in ASD-like defects in mice, including reduced social interactions and increased stereotyped behaviors, which are associated with hyperexcitability and increased levels of NMDA receptors. The reviewers suggest several revisions, including addressing the effect of memantine in Dlx-cKO mice, providing more representative images, and reporting exact p-values and statistical data. They also comment on the translational value of the mouse models, the use of different transgenic mice, and the consistency of western blot results. Overall, the reviewers find the study convincing and important for the CDD field and the community working on autism spectrum disorders.

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Description

Reviewers' comments on a study about CDKL5 deficiency disorder (CDD) and its relation to autism spectrum disorders (ASD).

Technical Information

File Format: PDF
File Size: 260 KB
Pages: 11
Language: EN
Author: Michael Rosch
Total Downloads: 105
Last Updated: 7 days ago

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